Hello, Welcome to LEAPChem.com

Source Quality Calcifediol (19356-17-3) from LEAPChem

Nov. 2019/1/10 15:23:43 By LEAP Chem


Searching for niche products has always been a problem. You have to spend much valuable time looking for a supplier, and then you need to make sure the provider is reputable. Usually, successfully finding a reputable, reliable, and responsible supplier of high quality chemicals must be a headache. Relax now, because those days are over! By coming to the LEAPChem website, you have come one step closer to acquiring your trouble free pharmaceutical chemicals. LEAPChem - Pharmaceutical Chemicals is proud to shed awareness on Calcifediol, a very promising chemical in the global chemical market.

 

Basic Information of Calcifediol

Chemical Name: Calcifediol

Cas No.: 19356-17-3

Molecular Formula: C27H44O2

Chemical Structure:

 19356-17-3.png

 

Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase which was isolated by Michael F. Holick. Physicians worldwide measure this metabolite to determine a patient's vitamin D status. At a typical daily intake of vitamin D3, its full conversion to calcifediol takes approximately 7 days.

Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation.

In medicine, a 25-hydroxy vitamin D (calcifediol) blood test is used to determine how much vitamin D is in the body. The blood concentration of calcifediol is considered the best indicator of vitamin D status.

This test can be used to diagnose vitamin D deficiency, and it is indicated in patients with high risk for vitamin D deficiency and when the results of the test would be used as supporting evidence for beginning aggressive therapies. Patients with osteoporosis, chronic kidney disease, malabsorption, obesity, and some other infections may be high risk and thus have greater indication for this test. Although vitamin D deficiency is common in some populations including those living at higher latitudes or with limited sun exposure, the 25(OH)D test is not indicated for entire populations. Physicians may advise low risk patients to take over-the-counter vitamin D in place of having screening.

It is the most sensitive measure, though experts have called for improved standardization and reproducibility across different laboratories. According to MedlinePlus, the normal range of calcifediol is 30.0 to 74.0 ng/mL. The normal range varies widely depending on several factors, including age and geographic location. A broad reference range of 20–150 nmol/L (8-60 ng/mL) has also been suggested, while other studies have defined levels below 80 nmol/L (32 ng/mL) as indicative of vitamin D deficiency.

Increasing calcifediol levels are associated with increasing fractional absorption of calcium from the gut up to levels of 80 nmol/L (32 ng/mL). Urinary calcium excretion balances intestinal calcium absorption and does not increase with calcifediol levels up to ~400 nmol/L (160 ng/mL).

A study by Cedric F. Garland and Frank C. Garland of the University of California, San Diego analyzed the blood from 25,000 volunteers from Washington County, Maryland, finding that those with the highest levels of calcifediol had a risk of colon cancer that was one-fifth of typical rates. However, randomized controlled trials failed to find a significant correlation between low-dosage (400iu/day) vitamin D supplementation and the risk of colon cancer.


As a verified ISO:9001 certified organization, we at LEAPChem demonstrate a high level of care in the distribution of our vast catalog of raw materials—accurately, on time, and on budget—by way of our knowledgeable sales specialists, thorough customer service and compliance departments, and cost-effective logistics management.


If you are interested in Calcifediol, click here to send an inquiry!

Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

 

References:

https://en.wikipedia.org/wiki/Calcifediol

https://www.ncbi.nlm.nih.gov/pubmed/28433267

https://www.ncbi.nlm.nih.gov/pubmed/28205055

 

Related Articles

Tributyltin (688-73-3) is on Sale at LEAPChem.com Now!

Source Ferrocene (102-54-5) from LEAPChem.com Now!

LEAPChem Supplies Inulin (9005-80-5) Now!