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Imipenem (74431-23-5) is Available on LEAPChem.com Now!

Nov. 2018/10/9 14:16:12 By LEAP Chem

LEAPChem is an ISO:9001 certified organization, which shows our high reputation track record for providing high quality management in the pharmaceutical chemicals industry. From initial inquiry through safe and efficient delivery, our team has the experience and professionalism to secure any pharmaceutical chemicals in your preferred grade, pack size and pack form, and deliver your products accurately, on time and on budget to every corner of the world. By coming to the LEAPChem - Pharmaceutical Chemicals website, you have come one step closer to acquiring your trouble free pharmaceutical chemicals. LEAPChem is happy to highlight Imipenem.


Basic Information of Imipenem

Chemical Name: Imipenem

Cas No.: 74431-23-5

Molecular Formula: C12H17N3O4S.H2O

Chemical Structure:



Imipenem (Primaxin) is an intravenous β-lactam antibiotic discovered by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in the mid-1970s. Carbapenems are highly resistant to the β-lactamase enzymes produced by many multiple drug-resistant Gram-negative bacteria, thus play a key role in the treatment of infections not readily treated with other antibiotics.

Imipenem was patented in 1975. It was discovered via a lengthy trial-and-error search for a more stable version of the natural product thienamycin, which is produced by the bacterium Streptomyces cattleya. Thienamycin has antibacterial activity, but is unstable in aqueous solution, so impractical to administer to patients. Imipenem has a broad spectrum of activity against aerobic and anaerobic, Gram-positive and Gram-negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species. It is not active against MRSA, however.

Imipenem acts as an antimicrobial through inhibiting cell wall synthesis of various Gram-positive and Gram-negative bacteria. It remains very stable in the presence of β-lactamase (both penicillinase and cephalosporinase) produced by some bacteria, and is a strong inhibitor of β-lactamases from some Gram-negative bacteria that are resistant to most β-lactam antibiotics.

Common adverse drug reactions are nausea and vomiting. People who are allergic to penicillin and other β-lactam antibiotics should take caution if taking imipenem, as cross-reactivity rates are low. At high doses, imipenem is seizurogenic.


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