Hello, Welcome to LEAPChem.com

Source High Quality Guanidine hydrochloride (50-01-1) from LEAPChem!

Nov. 2018/5/15 14:21:27 By LEAP Chem


LEAPChem - Pharmaceutical Chemicals is an ISO:9001 certified organization, which shows our high reputation track record for providing high quality management in the pharmaceutical chemicals industry. From initial inquiry through safe and efficient delivery, our team has the experience and professionalism to secure any pharmaceutical chemicals in your preferred grade, pack size and pack form, and deliver your products accurately, on time and on budget to every corner of the world. LEAPChem Highlights Guanidine hydrochloride today!

 

Basic Information of Guanidine hydrochloride

Chemical Name: Guanidine hydrochloride

Cas No.: 50-01-1

Molecular Formula: CH5N3.HCl

Chemical Structure:

50-01-1.png

 

Guanidinium chloride or guanidine hydrochloride, usually abbreviated GuHCl and sometimes GdnHCl or GdmCl, is the hydrochloride salt of guanidine. Guanidinium chloride is a strong chaotrope and one of the strongest denaturants used in physiochemical studies of protein folding. Guanidine Hydrochloride also has the ability to decrease enzyme activity and increase the solubility of hydrophobic molecules. At high concentrations of guanidinium chloride (e.g., 6 M), proteins lose their ordered structure, and they tend to become randomly coiled, i.e. they do not contain any residual structure. However, at concentrations in the millimolar range in vivo, guanidinium chloride has been shown to "cure" prion positive cells (i.e. cells exhibiting a prion positive phenotype revert to a prion negative phenotype). This is the result of inhibition of the Hsp104 chaperone protein known to play an important role in prion fiber fragmentation and propagation.

Guanidine hydrochloride is indicated for the reduction of the symptoms of muscle weakness and easy fatigability associated with Eaton-Lambert syndrome. It is not indicated for treating myasthenia gravis. It apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes. Initial dosage is usually between 10 and 15 mg/kg (5 to 7 mg/pound) of body weight per day in 3 or 4 divided doses. This dosage may be gradually increased to a total daily dosage of 35 mg/kg (16 mg/pound) of body weight per day or up to the development of side effects. Side effects include increased peristalsis and diarrhea. Fatal bone-marrow suppression, apparently dose related, can occur with guanidine.

As an experienced supplier of pharmaceutical chemicals for more than 10 years, LEAPChem is fully equipped to fill your pharmaceutical chemical requirements efficiently and exceed your expectations. Our customer service team is always ready to provide a personal touch to every conversation and ensure quick reply, professional support, and reliability at every step.


If you are interested in Guanidine hydrochloride, click here to send an inquiry!

Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

 

References:

https://en.wikipedia.org/wiki/Guanidinium_chloride

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142645/

https://www.ncbi.nlm.nih.gov/pubmed/19594171

 

Related Articles

LEAPChem Highlights Benzyladenine (1214-39-7)!

LEAPChem Supplies Hemin (16009-13-5) Now!

Buy Potassium clavulanate (61177-45-5) from LEAPChem.com Now!