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Find High Quality alpha-Arbutin (84380-01-8) from LEAPChem!

Nov. 2018/4/17 14:51:44 By LEAP Chem


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Basic Information of alpha-Arbutin

Chemical Name: alpha-Arbutin

Cas No.: 84380-01-8

Molecular Formula: C12H16O7

Chemical Structure:

 84380-01-8.png

 

Arbutin is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos among many other medicinal plants, primarily in the Ericaceae family. Applied topically, it inhibits tyrosinase and thus prevents the formation of melanin. Arbutin is therefore used as a skin-lightening agent. Very tiny amounts of arbutin are found in wheat, pear skins, and some other foods. It is also found in Bergenia crassifolia. Arbutin was also produced by an in vitro culture of Schisandra chinensis.

It works by slowly releasing hydroquinone through hydrolysis, which in turn blocks Tyrosinase activity and reduces the skin’s melanin (pigmentation) production. In cosmetics, this ingredient appears in two different forms: Alpha-Arbutin or Beta-Arbutin. Due to patenting concerns, most skin care products contain plant extracts that contain Arbutin (e.g. bearberry, pear, blueberry), rather than pure Arbutin. Used in a variety of cosmetics, particularly ones aimed at lightening the skin such as lotions, crèmes, serums, cleansers, and spot treatments.

Bearberry extract is used in skin lightening treatments designed for long term and regular use. An active agent in brands of skin lightening preparations, it is more expensive than traditional skin lightening ingredients like hydroquinone, which is now banned in many countries. In vitro studies of human melanocytes exposed to arbutin at concentrations below 300 μg/mL reported decreased tyrosinase activity and melanin content with little evidence of cytotoxicity.

 

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References:

https://en.wikipedia.org/wiki/Arbutin

https://www.ncbi.nlm.nih.gov/pubmed/15056856

https://www.ncbi.nlm.nih.gov/pubmed/8632348

 

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