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LEAPChem Highlights 2-Cyclohexen-1-one (930-68-7) Today!

Nov. 2018/4/12 14:22:56 By LEAP Chem

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Basic Information of 2-Cyclohexen-1-one

Chemical Name: 2-Cyclohexen-1-one

Cas No.: 930-68-7

Molecular Formula: C6H8O

Chemical Structure:



Cyclohexenone is an organic compound which is a versatile intermediate used in the synthesis of a variety of chemical products such as pharmaceuticals and fragrances. It is clear colorless liquid in pure state but a commercially available product is mostly yellowish liquid.

Industrially, cyclohexenone is prepared from phenol by Birch reduction. Cyclohexenone is a ketone, or more precisely an enone. Common reactions include nucleophilic conjugate addition with organocopper reagents, Michael reactions and Robinson annulations.

It is soluble in many solvents, such as alcohols, ethers, haloalkanes, esters, and also is miscible with polar aprotic solvents. Cyclohexenone reacts both ketones and alkenes. It has an electron-poor carbon-carbon double bond as a typical representative of the α, β-unsaturated carbonyl compounds. With strong bases, the positions 4 and 6 (the two CH2-groups of the carbonyl group and the C-C double bond adjacent) are deprotonated.

Cyclohexenone is a widely used building block in organic synthesis chemistry, as it offers many different ways to extend molecular frameworks. Cyclohexenone is easily adapted to Michael addition with nucleophiles (such as enolates or silyl enol ethers) or, it could be employed by a Diels-Alder reaction with electron-rich dienes. Furthermore, this compound reacts with organocopper compounds from 1,4-addition (Michael addition), or with Grignard reagents 1,2-addition, i.e., with attack of the nucleophile at the carbonyl carbon atom. Cyclohexenone is also used in multi-step synthesis in the construction of polycyclic natural products.

Cyclohexenone was accidentally found to be an in-vitro catalyst for a relatively mild decarboxylation of alpha amino acids in 1986. Researchers in Japan were attempting to use t-butyl peroxide as a catalyst for decarboxylation using a solvent choice of cyclohexanol. Curiously they found that when they used lower-purity (e.g. technical grade, 98%) cyclohexanol, the reaction proceeded as much as 4 times faster compared to when they used relatively pure cyclohexanol (>99.3%). They found that cyclohexanol contained cyclohexenone as a natural impurity, which was three times more abundant in the technical grade cyclohexenone compared to the more purified cyclohexanol (~0.3% versus ~0.1%). Further research showed that 1% cyclohexenone in cyclohexanol will decarboxylate most alpha-amino acids, including non-standard ones, with a yield of 80-95% in a matter of several hours. The exceptions are certain amino acids like histidine, which was reported to take over 26 hours, and poly-amino acids, which fail to decarboxylate using 2-cyclohexenone and another route must be found instead.


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